Raw material charge — adjust if needed, then print
!
Never mix bicarb and oxone directly — uncontrollable reaction will result. Prepare each solution separately. Oxone spills that dry create fire risk — rinse all spills immediately and thoroughly.
R1
Confirm glycol recirculating, valves open, chiller cooling.
R2
Charge acetone (— drums) to reactor bottom via dipleg. Confirm chiller at 21°F.
R3
Prepare bicarb solution — mix until fully dissolved. Charge to reactor. Start agitator.
R4
Charge kratom extract via top manway. Allow batch to return to target temperature.
R5
Oxone double-check, then prepare the oxone solution. Both operators must visually confirm the correct material before preparation begins.
Mix until fully dissolved. Do not prepare early — solution degrades on standing.
R6
Verify agitator is running on the reactor. Do not advance to oxone addition until confirmed.
R7
Add oxone solution slowly via pump over 1 hour. Start at 27°F or below.
R8
Hold at 0°C minimum 60 min. OK to hold indefinitely.
W1
Charge ethyl acetate via dipleg to reactor bottom. Agitate 25 min from start of EA addition.
W2
Stop agitator — both operators must verify before advancing.
W3
Settle 3 hrs minimum. Bump agitator 70 sec × 3 at 1-hr intervals. Record the time of each bump in the boxes below.
W4
Phase split — lower phase to tote. Conductivity 10–18 during split. Stop at ≤ 0.5. Total ≤ 1550 lbs.
If conductivity < 10: stop, bump 70 sec, settle 1 hr, retry.
W5
Water wash via spray nozzles (agitator off). Mix 2 min. Settle 60 min. Bump 70 sec. Settle. Split to tote — stop at conductivity ≤ 0.2. Target split: 400–500 lbs.
S1
Pump — lbs into large strip tank. Pump remainder (~— lbs) into medium stripper.
S2
Drain transfer line. Open the drain valve on the reactor-to-stripper line, collect residual contents in a bucket, and reseal the line.
CAUTION — pressurized line. Trapped solvent will expand as it warms and cause uncontrolled discharge or fitting failure. Line must be emptied after transfer. Wear face shield and safety glasses. Stand clear of fittings. Verify the line is fully depressurized before opening any fitting.
S3
Agitator off — settle 5 min. Install level gauge. Drain rag layer from sightglass until all water is gone. Seal manway. Start agitator. Verify cooling tower running.
S4
Open steam and condensate valves. Start boiler. At ~140°F adjust steam so cooling tower outlet is ~85°F. Monitor foam — reduce steam if foaming occurs.
S5
Continue stripping until level reaches the — mark on the red tape on the sightglass.
Target: — jugs total. Each jug ≈ 7.5 gal. Target ≥ 40 rotovap bowls. Final jug count and yield are reviewed at supervisor sign-off.
S6
Reactor cleanout: hose from top, pump all residue into totebin. Remove all bicarb residue to prevent discharge line plugging.
S1
Pump ~1,900 lbs into the bottom of the large strip tank. Pump the balance (~700 lbs) into the medium stripper. Hold the medium stripper until there is room to strip in the large stripper.
S2
Drain transfer line. Open the drain valve on the reactor-to-stripper line, collect residual contents in a bucket, and reseal the line.
CAUTION — pressurized line. Trapped solvent will expand as it warms and cause uncontrolled discharge or fitting failure. Line must be emptied after transfer. Wear face shield and safety glasses. Stand clear of fittings. Verify the line is fully depressurized before opening any fitting.
S3
Agitator off — settle 5 min. Install level gauge. Drain rag layer from sightglass until all water is gone. Seal manway. Start agitator. Verify large cooling tower running.
S4
Open steam and condensate valves. Start boiler. At ~140°F adjust steam so cooling tower outlet is ~85°F. Monitor foam — reduce steam if foaming occurs.
S5
When the large stripper is approximately half full, pump the balance from the medium stripper into the large stripper. Continue stripping off the solvent in the large stripper.
S6
Continue stripping until level reaches the 20 kg mark on the red tape on the sightglass.
Target: 12 jugs total. Each jug ≈ 7.5 gal. Final jug count and yield are reviewed at supervisor sign-off — over-stripped batches can be corrected at the rotovap, under-stripped batches simply take longer to process.
S7
Reactor cleanout: hose from top, pump all residue into totebin. Remove all bicarb residue to prevent discharge line plugging.
!
R-2500 procedure under development. Strip targets and step structure for the 2,500-gal reactor are not yet finalized. Verify with engineering before running a batch on R-2500. Steps shown above are inherited from R-600 as a placeholder only.
Deviations / downtime / observations
Batch close — supervisor review
Supervisor confirms: (1) batch record is complete and legible; (2) all critical-step verification signatures are present (R5 oxone double-check, W2 stop-agitator double-check, and all material weighings); (3) any deviations are documented above; (4) final jug count is within expected range — over-stripped batches can be corrected at the rotovap, under-stripped batches simply take longer to process.